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Coenzyme Q10 is a vital substance that every cell in your body requires. Commonly known as CoQ10, this fat soluble substance is made naturally in the body and is found in every human cell, primarily in the mitochondria. CoQ10 is found in highest concentrations in tissues with high energy turnover such as the heart, liver and kidney. 

Tissue levels of CoQ10 decrease with age. By the age of 40, our heart may be functioning with only about 68% of the CoQ10 we have at the age of 20. Low levels of CoQ10 are also being reported in patients with chronic diseases such as heart diseases, Parkinson’s disease, diabetes, cancers, kidney disorders and a number of other immunological conditions. Cholesterol lowering drugs ( Statins) are also known to reduce CoQ10 levels.

One may argue from the standpoint that lower dose might be more prudent but studies have consistently found that CoQ10 are safe and generally well tolerated with Observed Safety Level ( OSL) as high as 1200mg/day/person. You need to take enough Q10 to significantly raise its level in the blood to achieve therapeutic effects, averagely at 150mg/day.

CoQ10 is fat soluble. To ensure you are getting the most out of your CoQ10 supplement, it is important to choose a high strength bioactive formulation utilizing Effective Lipid Delivery System such as those found in Nutriva CoQ10 150mg. 

Solid scientific evidence have consistently suggest that the single most important factor in determining the bioavailability of CoQ10 is the carrier formulation; i.e : powder versus oil/lipid delivery system. As such, CoQ10 supplement in the form of pre-emulsified soft gel has been the best choice over the past few decades. 

CoQ10 is an essential compound vital to a number of activities related to energy metabolism. CoQ10 is used by cells to produce energy needed for cell growth and maintenance, and functions as antioxidant. CoQ10 appears to also provide cardioprotective and neuroprotective actions in the body.

Cardiovascular Indications 
Much of the basic research in support of CoQ10 supplementation has focused on the Congestive Heart Failure (CHF) model. The myocardium of patients with CHF demonstrates increased oxidative stress as well as decreased concentrations of CoQ10. 

The evidence for CoQ10 used in the cardiovascular settings is promising. Improvement was found in several parameters related to CHF among the more recent randomized controlled trials (2-4) including frequency of hospitalization, dyspnea and edema.

Diabetes Indications 
CoQ10 has been considered to improve glycemic control through various mechanisms, including decrease in oxidative stress. A more recent randomized controlled trial (n-74) using 200mg CoQ10 per day for 12 weeks displayed modest improvement in A1C levels.

Parkinson Indications 
A randomized, double blind, placebo-controlled, multicenter study of 80 patients found that CoQ10 was associated with up to 44 percent less functional decline, including activities of daily living. A study (8) of 28 patients with Parkinson’s disease also demonstrated mild symptom improvement with daily oral dosing of 360mg of CoQ10.

Migraine 
A preliminary open label trial (9) of 32 patients taking 150mg of Coenzyme Q10 daily demonstrated efficacy in reducing the frequency of migraine attacks. A recent randomized double blind, placebo controlled trial (10) of 42 patients taking CoenzymeQ10 at 300mg a day found similar benefits.

Exercise and work out
CoQ10 is sometimes promoted for improving physical ability or sports performance by enhancing the physical strength and stamina. The supplement may also help reduce fatigue after physical activities.